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As far back as 1969, classic sci-fi author Ursula K. LeGuin published "The Left Hand of Darkness," which explored a race of people who are by default androgynous until they are revealed to be also ambisexual, shifting genders from either male of female depending on environmental conditions.

“Your race is appallingly alone in its world. No other mammalian species. No other ambisexual species. No animal intelligent enough even to domesticate as pets. It must color your thinking, this uniqueness. I don’t mean scientific thinking only, though you are extraordinary hypothesizers—it’s extraordinary that you arrived at any concept of evolution, faced with that unbridgeable gap between yourselves and the lower animals. But philosophically, emotionally: to be so solitary, in so hostile a world: it must affect your entire outlook.”

She was best known for the Earthsea series, written for young adults, and The Left Hand of Darkness, set on a planet where everyone is ambisexual.

They can be ambisexual, nonmonogamous—even, as Frances claims to be, largely unemotional.

As an anthropologist sent to investigate humanity’s ambisexual descendants notes, while the social changes of gender fluidity seem small on the surface, in reality they are “incalculable.”