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Specifically, when ingested, the toxin targets the electrolyte pumps in the wall of the heart called the sodium potassium ATPase pump.

This ubiquitin tag is recognized by Ubx2, which triggers the recruitment of a protein called Cdc48 — a type of enzyme called an AAA ATPase.

The authors report that inhibiting the Na+, K+-ATPase in a human airway-cell model of cystic fibrosis prevented the beneficial effects of amphotericin B treatment.

Normally, protons re-enter the mitochondrial matrix through a membrane-spanning protein complex called the proton ATPase.

Hbs1–Dom34 and the ATPase Rli1 dissociate stalled ribosomes into 40S and 60S subunits.