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Homemade tonic syrups can cause cinchonism, a health condition related to ingesting too much quinine.

Quinine, a naturally occurring quinoline, and the earliest antimalarial drug, displayed a similar propensity to many of these effects, causing a syndrome known as cinchonism.

When the high temperature is only temporarily held in check, at the end of twenty-four hours, if all symptoms of cinchonism have disappeared, the same dose should be repeated.

Their action, too, is tonic, and, as they rarely produce cinchonism, the objection often made to the use of larger doses does not apply to them.

If the period which has elapsed since the beginning of the paroxysm is so considerable that further delay might prevent sufficient cinchonism to intercept the next accession.