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"Knowledge of the immune contexture is essential for understanding mechanisms of action and likelihood of prolonged response to CAR T-cell therapy. Collectively, these data may help inform studies evaluating patient management based on tumor biology and biomarkers, as well as the design of next-generation therapeutics," Locke said.

That biblical setting has a contemporary contexture: Death-dealing covid-19 and a corrosive political life are eating away at our very foundation.

But Boyle’s health had never been good, and as the diarist John Evelyn, an old friend, described his appearance in his later years: The contexture of his body, during the best of his health, appeared to me so delicate that I have frequently compared him to a chrystal, or Venice glass; which, though wrought never so thin and fine, being carefully set up, would outlast the hardier metals of daily use.

“I am close to both the child and her mother. The child wants to continue her pregnancy. We are considering the risks but she has a large contexture, she weighs more than 50 kilos,” Vigliocco said in a radio interview.

We are all framed of flaps and patches, and of so shapeless and diverse a contexture, that every piece and every moment playeth his part.