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Moreover, 400 insertions showed highly polymorphic frequency variability across the populations, and 76 of them, including 45 genic insertions, were Asian specific.

Quantification of genic intolerance to both classes of variation will provide added power to disease studies.

Our analysis of genic mCH across human tissues indicates a tissue-specific distribution that is distinct from those genes that were previously identified in embryonic stem cells and the brain.

Bar plot show their overlap with indicated functional genic annotations.

In brief, we applied ChIPpeakAnno to assign factor binding to genic targets and to evaluate the enrichment of genic targets for GO ontologies using standard procedures36.