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Holoblastic, hol-o-blas′tik, adj. undergoing segmentation throughout the entire mass, as the ova of mammals.

Broadly speaking, they fall first into two groups: the older cyclostoma, the earliest fishes, most of the amphibia, and the viviparous mammals, have holoblastic ova—that is to say, ova with total, unequal segmentation; while the younger cyclostoma, most of the fishes, the cephalopods, reptiles, birds, and monotremes, have meroblastic ova, or ova with partial discoid segmentation.

Although the mass of the food-yelk may be very large in the ova of the discoblastic vertebrates, nevertheless in every case a blastula is developed from the morula, as in the holoblastic ova.