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It was only occasionally that she showed a tinge of irritation when asked about Italy's low defence spending.

While some people don’t react at all, others experience severe skin irritation.

But Trump's irritation with Europe is nothing new.

Sniffing alkyl nitrites can cause skin irritation, dizziness, low blood pressure, headaches and other unpleasant side effects.

“A group of sweet seniors shyly asked Costner to pose for a picture with them as he waited at a red light, tapping his cowboy boot in irritation.”