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In addition to further testing the Subak reporter for nuclease digestion, the team also wants to investigate whether it can be a probe for other biological targets.

In contrast to gene scissors, however, the CRISPRi nuclease only binds to the DNA without cutting it.

SIR2's first job as a nuclease is digesting nucleic acids to maintain proper cell functions.

But soon after fertilization, the nuclease cuts the DNA sequence on the other chromosome from the parent that did not carry the gene at the precise location of the gene drive.

It took Dr. Bao’s lab more than two years of development, and then zinc finger nuclease would successfully cut the sickle cell sequence only around 10 percent of the time.