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During chronic Dox treatment, iWnt mice and mammary tumours phenocopy their cWnt counterparts, but iWnt tumours regress following Dox withdrawal owing to abrogation of transgene expression.

These mice accumulate progerin, present histological and transcriptional alterations characteristic of progeroid models, and phenocopy the main clinical manifestations of human HGPS, including shortened life span and bone and cardiovascular aberrations.