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Smout’s doubts persisted until he and colleagues studied a small group of patients a few years ago.

André Smout, a gastroenterologist at the University of Amsterdam in the Netherlands, said he read those reports when they came out.

“We had to admit that it really existed,” Smout said.

Culture Perth and Kinross's chief executive Helen Smout said the museum was probably the biggest cultural project Perth had seen in two centuries.

Ms Smout said that although it took a while to settle on the building, it had been "a lightbulb moment" when the decision was finally made.