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The main metabolite, aminomethylphosphonic acid, was detected in the brains of both normal and transgenic mice with Alzheimer's pathology.

Transgenic mice are genetically modified to carry genes that cause them to develop Alzheimer's-like symptoms as they age.

The study, "Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models," appears in the November 26 issue of Cell Reports.

The introduction of the CRISPR/Cas9 method represented a methodological breakthrough for the researchers, as it enabled the establishment of the first transgenic migratory locusts expressing the genetically encoded calcium sensor GCaMP in olfactory sensory neurons.

Interestingly, the transgenic plants also showed improved resilience to chilling stress, a common environmental challenge that can severely impact crop yields.