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Amitriptyline belongs to a group of medications called tricyclics.

First there were tricyclic antidepressants, then there were SSRIs like Prozac and SNRIs like Cymbalta, drugs that target neurotransmitters such as serotonin and norepinephrine.

For older patients, the most commonly prescribed inappropriate medicines include proton pump inhibitors like Nexium and Prilosec, benzodiazepines like Xanax and Ativan, and tricyclic antidepressants, according to an analysis of Medicare data published last year.

Other deadly single pills include antimalarials, tricyclic antidepressants, beta blockers and calcium channel blockers.

For example, cancer patients with pain as a result of nerve damage caused by chemotherapy might first be treated with paracetamol and a tricyclic antidepressant.