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ETC-1002 interferes with cholesterol synthesis and carbohydrate metabolism by inhibiting ATP-citrate lyase  and activating a complementary enzyme, AMPK. For now Esperion is focusing on its LDL cholesterol lowering effects and, following the strategy of the PCSK9s, hopes to gain an initial approval for patients who can’t tolerate statins.

The drug inhibits ATP-citrate lyase and may have additional effects associated with activation of AMP-activated kinase.

Abundance and genetic diversity of microbial polygalacturonase and pectate lyase in the sheep rumen ecosystem.

GenPath's test, on the other hand, has the potential to identify a host of additional diseases: 3-Hydroxy-3-Methylglutaryl CoA lyase deficiency, for example, is diagnosed when a person can't process an amino acid called leucine.

GenPath says it is the most comprehensive screen currently offered: in a field of rare diseases, the test distinguishes itself by scanning for 95 disorders that are not screened for by any other company, including obscure tongue-twisters such as 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and cerebrotendinous xanthomatosis.